GM-CSF plays a key role in zymosan-stimulated human dendritic cells for activation of Th1 and Th17 cells

NCU Institutional Repository > 生醫理工學院 > 生命科學系 > 期刊論文 > Item 987654321/50822

jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.lib.ncu.edu.tw/handle/987654321/50822

题名:	GM-CSF plays a key role in zymosan-stimulated human dendritic cells for activation of Th1 and Th17 cells
作者:	Wei,WC;Su,YH;Chen,SS;Sheu,JH;Yang,NS
贡献者:	生命科學系
关键词:	TUMOR-NECROSIS-FACTOR;CANCER-IMMUNOTHERAPY;IMMUNOLOGICAL-TOLERANCE;IMMUNE-RESPONSE;T-CELLS;INFLAMMATION;DECTIN-1;VACCINE;INTERLEUKIN-12;PROMOTES
日期:	2011
上传时间:	2012-03-27 18:10:44 (UTC+8)
出版者:	國立中央大學
摘要:	In this study, we compared the effects of zymosan and LPS on human monocyte-derived dendritic cells. The specific effects of zymosan on the expression of several key cytokines, including granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukins (IL-1 alpha, IL-1 beta and IL-12 p70) were quite distinct from the effects of LPS. Unlike activation with LPS, DCs activated by zymosan expressed little or no IL-12 p70 due to lack of expression of the p35 subunit. However, treatment with zymosan resulted in a substantial increase in Th1 and Th17 cell-polarizing capacity of DCs. Furthermore, the GM-CSF secreted by zymosan-activated DCs enhanced IL-23 production, resulting in activation of a Th17 response. GM-CSF and IL-27, rather than IL-12 p70, were both major direct contributors to the activation of a Th1 response. This signaling mechanism is distinct and yet complementary to LPS-mediated T-cell activation. We suggest that this novel zymosan-induced GM-CSF-mediated signaling network may play a key role in regulating specific immune cell type activities. (C) 2011 Elsevier Ltd. All rights reserved.
關聯:	CYTOKINE
显示于类别:	[生命科學系] 期刊論文

文件中的档案:

档案	描述	大小	格式	浏览次数
index.html		0Kb	HTML	635	检视/开启

在NCUIR中所有的数据项都受到原著作权保护.

社群 sharing

数据加载中.....