Fenthion and Terbufos Induce DNA Damage, the Expression of Tumor-Related Genes, and Apoptosis in HepG2 Cells

NCUIR > college of Health Sciences and Technology > Department of Life Science > journal & Dissertation > Item 987654321/50819

Please use this identifier to cite or link to this item: http://ir.lib.ncu.edu.tw/handle/987654321/50819

Title:	Fenthion and Terbufos Induce DNA Damage, the Expression of Tumor-Related Genes, and Apoptosis in HepG2 Cells
Authors:	Wu,JC;Hseu,YC;Tsai,JS;Chen,LC;Chye,SM;Chen,CH;Chen,SC
Contributors:	生命科學系
Keywords:	GEL-ELECTROPHORESIS ASSAY;HUMAN-LYMPHOCYTES;COMET ASSAY;RAT-LIVER;C-MYC;GENOTOXICITY;JUN;MITOCHONDRIAL;HEPATOCYTES;ACTIVATION
Date:	2011
Issue Date:	2012-03-27 18:10:41 (UTC+8)
Publisher:	國立中央大學
Abstract:	This study investigates the effects of fenthion and terbufos, two organophosphorous pesticides, on DNA damage, tumor-related gene expression, and apoptosis in HepG2 cells. We found that exposure to concentrations ranging from 50 to 200 mu M of fenthion and terbufos for 2 hr caused significant death in HepG2 cells. Both compounds induced DNA damage in a concentration-dependent manner as measured using the alkaline comet assay. Tumor-related genes (jun, myc, and fos) and apoptosis-related genes (socs3, tnfaip3, ppp1r15a, and nr4a1) were up-regulated by both compounds. Finally, both compounds induced apoptosis. The results demonstrate that both terbufos and fenthion induce DNA damage and should be considered potentially hazardous to humans. Environ. Mol. Mutagen. 52:529-537, 2011. (C) 2011 Wiley-Liss, Inc.
Relation:	ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
Appears in Collections:	[Department of Life Science] journal & Dissertation

Files in This Item:

File	Description	Size	Format
index.html		0Kb	HTML	579	View/Open

社群 sharing